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KMID : 1024720170070010011
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Geriatric Rehabilitation
2017 Volume.7 No. 1 p.11 ~ p.19
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Biomarkers in Sarcopenia : Based on Pathophysiologic Mechanisms
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Lee Seung-Yeol
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Abstract
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Sarcopenia is an emerging giant issue, which represents an important health problem, being related to a condition of disability. The diagnosis of sarcopenia generally requires the presence of low muscle mass with either low grip strength or low physical performance. However, cut-off value of elements for the diagnosis of sarcopenia is slightly different among the working groups. The lack of unique diagnostic criteria and the complex underlying pathophysiology make the development of biomarkers extremely challenging. The complex factors affecting age-related skeletal muscle changes include alterations of the neuromuscular junction, endocrine system, growth factors, muscle protein turnover, behavior-related and inflammation related factors. Several candidates for biomarkers of sarcopenia according to the above pathophysiologic mechanisms have been developed. However, because of its multifactorial pathogenesis, a speculative model by the multidimensional approach may be needed.
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KEYWORD
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Sarcopenia, Biomarker, Mechanism
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